Prof. Dr. Michael Wiese (retired)

Pharmazeutisches Institut
Pharmazeutische und Zellbiologische Chemie
An der Immenburg 4
53121 Bonn

Fax: +49-228-737929
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Prof. Dr. M. Wiese - Publications

 Titel   Typ 
Effect of cyclodextrin derivatives on indomethacin stability in aqueous solution. Journalartikel
Quantitative and explicit structure-time-activity relations. Journalartikel
A time hierarchy-based model for kinetics of drug disposition and its use in quantitative structure-activity relationships. Journalartikel
A kinetic description of the fate of chemicals in biosystems. Journalartikel
The inactivation of lipoxygenase-1 from soybeans by amidrazones. Journalartikel
A comparative analysis of the synergistic interaction between N1-phenylsulfanilamides and benzylpyrimidines using qsar techniques. Journalartikel
Inhibition of the conjugation of PABA with glycine in vitro by sulfamoyl benzoic acids, sulfonamides, and penicillins and its relation to tubular secretion Journalartikel
Three-dimensional quantitative structure-activity relationship analysis of propafenone-type multidrug resistance modulators: influence of variable selection on test set predictivity. Journalartikel
Ionization constants and distribution coefficients of phenothiazines and calcium channel antagonists determined by a pH-metric method and correlation with calculated partition coefficients. Journalartikel
Lipoxygenase inhibitors, Part 6. Synthesis of new tetrahydropyrazine and other heterocyclic compounds by reaction of hydrazonoyl chlorides. Journalartikel
Identification of putative binding sites of P-glycoprotein based on its homology model. Journalartikel
Structure-activity relationships of a series of tariquidar analogs as multidrug resistance modulators. Journalartikel
Differential gene expression studies in cisplatin-sensitive versus cisplatin-resistant human cancer cell lines. Journalartikel
Identification of new genes involved in cisplatin resistance and their expression profile in 18 human tumor cell lines. Journalartikel
Molecular dynamics simulation of the human adenosine A3 receptor: agonist induced conformational changes of Trp243. Journalartikel
Dibenzazecine compounds with a novel dopamine/5HT2A receptor profile and 3D-QSAR analysis. Journalartikel
Comparison of azacyclic urea A-98881 as HIV-1 protease inhibitor with cage dimeric N-benzyl 4-(4-methoxyphenyl)-1,4-dihydropyridine as representative of a novel class of HIV-1 protease inhibitors: a molecular modeling study. Journalartikel
Synthesis and biological evaluation of the first N-alkyl cage dimeric 4-aryl-1,4-dihydropyridines as novel nonpeptidic HIV-1 protease inhibitors. Journalartikel
Functional comparison of single- and double-stranded mdr1 antisense oligodeoxynucleotides in human ovarian cancer cell lines. Journalartikel
Novel tetrahydroisoquinolin-ethyl-phenylamine based multidrug resistance inhibitors with broad-spectrum modulating properties. Journalartikel
In vitro and in vivo evaluation of WK-X-34, a novel inhibitor of P-glycoprotein and BCRP, using radio imaging techniques. Journalartikel
Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative. Journalartikel
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators. Journalartikel
The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba. Journalartikel
A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins. Journalartikel
Comparison of the usefulness of the MTT, ATP, and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines. Journalartikel
New functional assay of P-glycoprotein activity using Hoechst 33342. Journalartikel
Novel modulators to overcome P-glycoprotein-mediated multidrug resistance in tumor cells. Journalartikel
Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Journalartikel
Phenylnannolones A-C: biosynthesis of new secondary metabolites from the myxobacterium Nannocystis exedens. Journalartikel
Molecular modeling of phenothiazines and related drugs as multidrug resistance modifiers: a comparative molecular field analysis study. Journalartikel
Structure-function relationships of multidrug resistance P-glycoprotein. Journalartikel
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). Journalartikel
Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability. Journalartikel
Microionization constants: novel approach for the determination of the zwitterionic equilibrium of hydroxyphenylalkylamines by photometric titration. Journalartikel
Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2). Journalartikel
Preparation and biological activity of new substituted antimalarial diaminodiphenylsulfones. Journalartikel
Studies on 2,3,N,N'-substituted 4,4'-diaminodiphenylsulfones as potential antimalarial agents. Journalartikel
Partial resistance of E. coli mutants against 2, 4-diamino-5-benzylpyrimidines by interactions with bacterial membrane lipopolysaccharides. Derivation of quantitative structure-binding relationships. Journalartikel
Polyketides from the marine-derived fungus Ascochyta salicorniae and their potential to inhibit protein phosphatases. Journalartikel
Drug membrane interaction and the importance for drug transport, distribution, accumulation, efficacy and resistance. Journalartikel
Strategies in the development of new drugs and drug combinations against leprosy, demonstrated on the example of folate and gyrase inhibitors. Journalartikel
QSAR and multivariate data analysis of the interaction of amphiphilic drugs with phospholipids. Journalartikel
A new method to evaluate the consolidation behavior of pharmaceutical materials by using the Fraser-Suzuki function. Journalartikel
Molecular rigidity and potency of bispyridinium type allosteric modulators at muscarinic M2-receptors. Journalartikel
Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. Journalartikel
Pyrimethamin-resistant Plasmodium falciparum lack cross-resistance to methotrexate and 2,4-diamino-5-(substituted benzyl) pyrimidines. Journalartikel
Molecular modeling of beta-cyclodextrin drug inclusion complexes based on NMR-interaction measurements. Journalartikel
Interaction of prostaglandin E1 with alpha-cyclodextrin in aqueous systems: stability of the inclusion complex. Journalartikel
Development of an in vitro drug screening system for Mycobacterium leprae based on the determination of the intrabacterial sodium to potassium ratio of individual bacterial organisms. Journalartikel
Structure-activity relationships of multidrug resistance reversers. Journalartikel
Molecular modeling study of the multidrug resistance modifiers cis- and trans-flupentixol. Journalartikel
New antifolate 4,4'-diaminodiphenyl sulfone substituted 2,4-diamino-5-benzylpyrimidines. Proof of their dual mode of action and autosynergism. Journalartikel
Drug effects on intracellular mycobacteria determined by mass spectrometric analysis of the Na(+)-to-K+ ratios of individual bacterial organisms. Journalartikel
3D-QSAR with the aid of pharmacophore search and docking-based alignments for farnesyltransferase inhibitors Journalartikel
PDFs PDF-Ordner
Characterization of 3-methoxy flavones for their interaction with ABCG2 as suggested by ATPase activity. Journalartikel
In Memoriam: Prof. Dr. Joachim K. Seydel. Journalartikel
8-Benzyltetrahydropyrazino[2,1-f]purinediones: Water-Soluble Tricyclic Xanthine Derivatives as Multitarget Drugs for Neurodegenerative Diseases. Journalartikel
How liposomal cisplatin overcomes chemoresistance in ovarian tumour cells. Journalartikel
Application of in Silico methods to study ABC transporters involved in multidrug resistance. Tagungsbeitrag
Protein Contacts and Ligand Binding in the Inward-Facing Model of Human P-Glycoprotein. Journalartikel
Accessing cancer metabolic pathways by the use of microarray technology. Journalartikel
Overcoming chemotherapy resistance of ovarian cancer cells by liposomal cisplatin: Molecular mechanisms unveiled by gene expression profiling. Journalartikel
Gene expression signatures of angiocidin and darapladib treatment connect to therapy options in cervical cancer. Journalartikel
Synthesis and Quantitative Structure-Activity Relationships of Selective BCRP Inhibitors. Journalartikel
4-Substituted-2-phenylquinazolines as inhibitors of BCRP. Journalartikel
HG-829 Is a Potent Noncompetitive Inhibitor of the ATP-Binding Cassette Multidrug Resistance Transporter ABCB1. Journalartikel
Tyrosine Kinase Inhibitors Influence ABCG2 Expression in EGFR-Positive MDCK BCRP Cells via the PI3K/Akt Signaling Pathway. Journalartikel
Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. Journalartikel
A Microarray Tool Provides Pathway and GO Term Analysis. Journalartikel
Recombinant Synthesis of Human ABCG2 Expressed in the Yeast Saccharomyces cerevisiae: An Experimental Methodological Study. Journalartikel
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). Journalartikel
Total Synthesis of Natural and Non-Natural Δ5,6Δ12,13-Jatrophane Diterpenes and Their Evaluation as MDR Modulators. Journalartikel
Anticancer effects of the nitric oxide-modified saquinavir derivative saquinavir-NO against multidrug-resistant cancer cells. Journalartikel
Specific Inhibitors of the Breast Cancer Resistance Protein (BCRP). Journalartikel
NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-α,α'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. Journalartikel
Novel lead for potent inhibitors of breast cancer resistance protein (BCRP). Journalartikel
Structure-activity relationships of tariquidar analogs as multidrug resistance modulators. Journalartikel
Comparison of the inward- and outward-open homology models and ligand binding of human P-glycoprotein. Journalartikel
Activators of P-glycoprotein: Structure-Activity Relationships and Investigation of their Mode of Action. Journalartikel
Combined Pharmacophore Modeling, Docking, and 3D QSAR Studies of ABCB1 and ABCC1 Transporter Inhibitors. Journalartikel
Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity. Journalartikel
Aromatic 2-(Thio)ureidocarboxylic Acids As a New Family of Modulators of Multidrug Resistance-Associated Protein 1: Synthesis, Biological Evaluation, and Structure-Activity Relationships. Journalartikel
Drug-membrane interaction and its importance for drug efficacy. Tagungsbeitrag
Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. Journalartikel
Computational aqueous solubility prediction for drug-like compounds in congeneric series. Journalartikel
In silico models for interactions with transporters. Tagungsbeitrag
Algorithms to predict affinity for transporters. Journalartikel
Computer simulation of phospholipids and drug-phospholipid interactions. Journalartikel
Multidrug resistance related drugs: Part I. Estimation of hydrophobicity as a space directed molecular property. Journalartikel
Synthesis, selective aldose reductase inhibitory profile and antihyperglycemic potential of certain parabanic acid derivatives. Journalartikel
Human P-glycoprotein pseudoreceptor modeling: 3D-QSAR study on thioxanthene type multidrug resistance modulators. Journalartikel
Comparative molecular field analysis of multidrug resistance modifiers. Tagungsbeitrag
QSAR analysis of substituted 2-phenylhydrazonoacetamides acting as inhibitors of 15-lipoxygenase. Journalartikel
A comparative molecular field analysis of inhibitors of tubulin polymerization. Journalartikel
Interpretation of CoMFA results - a probe set study using hydrophobic fields. Journalartikel
A comparative molecular field analysis of propafenone-type modulators of cancer multidrug resistance. Journalartikel
Determination of dissociation constants of cephalosporins by capillary zone electrophoresis. Journalartikel
3D-QSAR analysis and molecular modeling investigations of piritrexim and analogs. Journalartikel