2024
- Dr. Tim Keuler
Development of Molecular Chimeras Targeting the NLRP3 Inflammasome and HDAC6
2023
- Dr. Lan Phuong Vu
Tool Compounds to Study Proteolytical Events: Development of von Hippel-Lindau (VHL) Ligands and Combinatorial Generation of Serine Protease Inhibitors
2022
- Dr. Carina Wirtz
Synthesis and Bioanalytical Evaluation of Inhibitors and Tool Compounds for Human, Protozoal, and Viral Cysteine Proteases
2014
- Dr. Matthias Mertens
Coumarin, a Versatile Scaffold in Pharmaceutical Chemistry: Fluorescent Labeling of Amino Acids, Activity-Based Probing of Human Cathepsin S, Monoamine Oxidase B Inhibition and Chiral Derivatization
2013
- Dr. Eva Maurer
Characterisation of the type II transmembrane serine protease matriptase-2: Analysis of expression, activity modulation and enzyme-ligand interaction
2012
- Dr. Philipp Aaron Ottersbach
Investigations on Atropisomerism in Azadipeptides and Preparation of Conformationally Constrained Azadipeptides
-
Dr. Maxim Frizler
Development of Selective Nitrile Inhibitors and 'Activity-Based' Probes for Human Cathepsins K and S
2011
- Dr. Stefan Dosa
Sulfamoylbenzamidine als Arginin-Mimetika: Hemmung von Trypsin-artigen Serinproteasen und Mapping des aktiven Zentrums von Matriptase-2
2010
- Dr. Mihiret Tekeste Sisay
Virtual compound screening and SAR analysis: method development and practical applications in the design of new serine and cysteine protease inhibitors
-
Dr. Hans-Georg Häcker
Substituted Aromatic (Thio)ureas and Derived Heterocycles as Modulators of P-Glycoprotein and Multidrug Resistance-Associated Protein 1
2008
- Dr. Camino M. Gonzalez
Enzymkinetische Charakterisierung niedermolekularer Verbindungen als Inhibitoren von Serinhydrolasen
2007
- Dr. Paul Wilhelm Elsinghorst
Dual-mode cholinesterase inhibitors targeting muscarinic receptors
2006
- Dr. Reik Löser
Synthese von Dipeptid-Derivaten und deren Interaktion mit Papain-ähnlichen Cysteinproteasen unter besonderer Berücksichtigung von Dipeptidnitrilen
- Dr. Sonja Kolp
Untersuchungen zur Beeinflussung der Zymogen-Aktivierung durch kompatible Solute und zur proteolytischen Aktivität von Matriptase-2
- Dr. Agnieszka Ambrozak
Synthesis of 5-Aminobarbituric Acids and Their Conversion to Hydantoins and Bioactive Phthalimido Derivatives
- Dr. Markus Pietsch
Synthese tricyclischer 1,3-Oxazin-4-one und kinetische Analyse der Hemmung der Cholesterolesterase und der Acetylcholinesterase
2005
- Dr. Manuela Meusel
Entwicklung neuer Syntheseverfahren für biologisch aktive Ureide und Hydantoine
2024
-
Alexandra Maria Hingst
Kinetik Investigation on Reactions Catalyzed by the Main Protease of SARS-CoV-2 - Vesa Krasniqi
Enzyme Kinetic Investigations on Inhibition of Cathepsins and Monoamine Oxidases
by Low Molecular Weight Compounds
2023
-
Johannes Sievers
N.N. - Elsjon Sula
Synthesis of PET Precursors for VHL-based PROTACs
2022
- Marie Möller
Synthesis and Characterization of a New Non-covalent KEAP1 Ligand for PROTAC Applications
- Sophie Wittenburg
Synthesis and Physicochemical Characterization of PROTACs Targeting RAF Kinases
2020
- Sabine Anna Voell
Synthesis of PROTACs Targeting BRAF(V600E)
2019
- Dominik Brajtenbach
Synthesis of Cyanine-Containing Activity-Based Probes for Cathepsin-K
- Jiafei Yin
Biochemical Investigation of Inhibitors and Tool Compounds for Different Human Proteases, Esterases and Oxidases
2018
- Lan Phuong Vu
Synthesis of E3 Ligase Ligands as Building Blocks for PROTACs
- Seyda Teke
Synthesis of Dipeptidomimetic Carbamates as Cathepsin B Inhibitors and Precursors for Positron Emission Tomography
2017
- Franziska Kohl
Synthesis and Biological Evaluation of a Novel BIP-V5 Containing PROTAC Targeting the Human Bax Protein
- Carina Lemke
Development and Enzymatic Characterization of Covalent Inhibitors Adressing Various Human Cathepsins
2016
- Christian Steinebach
Design of Phthalimide-Conjugates for Bifunctional Ligand-Based Target Protein Degradation
- Polya Georgieva Roydeva
Untersuchung zur Hemmung von Matriptase-2 durch ausgewählte heterocyclische Verbindungen
- Lisa Reinelt
Synthese analoger BIM-46187-Derivate
- Tianwei Li
Kinetic Evaluation and Structural Optimization of Dipeptidyl Nitrile Type Cathepsin B Inhibitors
2015
- Laura Cremer
Synthesis of Dipeptide Carbamates and Dipeptide Carbonates as Inhibitors of Cysteine proteases
- Tamara Scheidt
Kinetic Investigations on Pharmaceutically Relevant Serine and Cysteine Proteases with Selected Protease Inhibitors
- Martin Mangold
Untersuchungen zur Reinigung und Aktivitätsregulation der rekombinanten humanen Serinprotease Matriptase-2
2013
- Karina Scheiner
Affibody-based Enzyme Scaffolds for Metabolic Engineering of E. coli and Cyanobacteria for Improved PHB and Butanol Production in Vivo (Universität Bonn / Royal Institute of Technology, Stockholm)
- Anna Beckmann
Synthesis of 3-Cyano-3-aza-ß-amino Acid Derivatives as Potential Inhibitors of Human Cysteine Proteases
- Verena Lülsdorff
Charakterisierung von Hepatocyte Growth Factor Activator Type 1 (HAI-1) als Inhibitor der Serinprotease Matriptase-2
- Michael Lülsdorff
Synthesis of Dipeptidomimetics with Inversely Oriented Warheads and their Inhibitory Activity Against Cathepsin B
- Katharina Arenz
Evaluation of Nitroxoline-Related Compounds in a 3D In Vitro Tumour Invasion Model (Universität Bonn / University of Ljubljana)
2012
- Franziska Krumbiegel
Methodenvalidierung eines Alkoholmarkers in Mekonium (Universität Bonn / Institut für Rechtsmedizin der Charité Berlin)
2011
- Daniela Häußler
Synthese Fluoreszenz-markierter Serinprotease-Inhibitoren
- Janina Schmitz
Synthesis and Evaluation of P2-Modified Dipeptide Nitriles as Inhibitors of Cathepsin S
2009
- Matthias Mertens
Synthesis of N- and O-sulfonylated 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine / Quinazoline Derivatives and Observation of a N-O Sulfonyl Transfer
- Eva Maurer
Charakterisierung des Aktivierungsmechanismus der Trypsin-ähnlichen Serinprotease Matriptase-2
2012
- Lukáš Hroch
Preparation of 3,5,5-Trisubstituted Hydantoins From Activated Cbz-Aminomalonic Acids (Universität Bonn / Univerzita Karlova v Praze)
2009
- Friederike Lohr
Aza-Dipeptidnitrile als potentielle Cysteinprotease-Hemmstoffe: Synthese und enzymkinetische Untersuchungen
- Philipp Aaron Ottersbach
Synthese von potentiell biologisch aktiven Benzo[1,2-d:4,3-d']bisthiazolen und 3,1-Benzothiazinen
2008
- Cornelius Heß
17-Hydroxymethyl-17-methyl-18-nor-Derivate als Metaboliten von anabolen androgenen 17alpha-Methyl-Steroiden - massenspektrometrische Charakterisierung und renale Elimination (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln)
- Maxim Frizler
Azadipeptidnitrile als Proteaseinhibitoren: Synthese, Stabilität und Papain-Hemmung
2007
- Mihiret Tekeste Sisay
Homology Modeling and Structural Analysis of the Catalytic Domain of Matriptase-2
- Anne-Katrin Orlovius
Metabolismus von Stimulanzien: Synthese und direkte Bestimmung von Sulfat-Konjugaten. Ein Beitrag zur Weiterentwicklung des Nachweisverfahrens in der Dopinganalytik (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln)
2006
- Eva Lepicova
Investigations on the Darzens Condensation of 2-Bromo-4,6-dimethoxybenzofuran-3(2H)-one (Universität Bonn / Univerzita Karlova v Praze)
- Jürgen Gäb
Synthese von 4H-3,1-Benzothiazin-4-on-Derivaten als potentielle Liganden von Adenosin-Rezeptoren
2004
- David Bolek
Syntéza derivátu alfitoninu (Universität Bonn / Univerzita Karlova v Praze)
2002
- Ales Marecek
Syntéza 2-benzyl-2-hydroxy-2H-benzofuran-3-onu (Universität Bonn / Univerzita Karlova v Praze)
- Abdelazim Sarhan
Untersuchungen zur Synthese und zur D-Hydantoinase-katalysierten Hydrolyse von Hydantoinen
2001
- Markus Pietsch
Untersuchungen zur Wechselwirkung von Pankreas-Cholesterolesterase mit niedermolekularen Verbindungen
2000
- Lars Kuerschner
Untersuchungen zur Enzymkinetik und zur Enzym-Ligand-Wechselwirkung von Cathepsin G-Inhibitoren