Forschungsergebnisse

T Claff, R Ebenhoch, JT Kley, A Magarkar, H Nar, D Weichert. Structural basis for lipid-mediated activation of G protein-coupled receptor GPR55; Nature Communications 16 (1), 1973

C Bi, S Mirza, H Baburi, L Schäkel, R Winzer, Moschütz, K Keetz, V Lopez, J Pelletier, J Sévigny, J Schulze zur Wiesch, T Claff, E Tolosa, V Namasivayam, N Sträter, CE Müller. Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5′-Monophosphate; ACS pharmacology & translational science 8 (5), 1401-1415

RM Idris, H Al-Hroub, CC Schmies, P Riziki, C Renn, T Claff, K Sylvester, S Moschütz, J Reinhardt, W Deuter-Conrad, JM Dietrich, M Toma, BK Fleischmann, D Wenzel, H Zimmermann, M Hölzel, N Sträter, CE Müller. Design, development and evaluation of a tritium-labeled radiotracer for ecto-5’-nucleotidase (CD73) – A versatile research tool and diagnostic agent for personalized medicine; Biomedicine & Pharmacotherapy 188, 118115

J Nagel, V Namasivayam, S Weinhausen, J Sierra-Marquez, Y Baqi, H AM Al Musawi, Abdelrahman, VJ Vaaßen, JG Schlegel, L Taplick, J Torp, J Kubicek, B Maertens, M Geyer, T Claff, A Nicke, G Hagelueken, CE Müller. Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor; Nature communications 16 (1), 10367

J Breidenbach, R Voget, Y Si, A Hingst, T Claff, K Sylvester, V Wolf, V Krasniqi, A Useini, N Sträter, Y Ogura, A Kawaguchi, CE Müller, M Gütschow. Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs; Journal of Medicinal Chemistry 67 (11), 8757-8790

T Claff, AB Mahardhika, VJ Vaaßen, JG Schlegel, C Vielmuth, R H Weiße, N Sträter, CE Müller. Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A2A Receptor; ACS pharmacology & translational science 7 (5), 1415-1425

A Oneto, G Al Hamwi, L Schäkel, N Krüger, K Sylvester, M Petry, R Abu Shamleh, T Pillaiyar, T Claff, AC Schiedel, N Sträter, MGütschow, CE Müller. Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity; ACS pharmacology & translational science 7 (5), 1415-1425

R Voget, J Breidenbach, T Claff, A Hingst, K Sylvester, C Steinebach, L Phuong Vu, RH Weiße, U Bartz, N Sträter, CE Müller, M Gütschow. Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics; Acta Pharmaceutica Sinica B 14 (5), 2349-2357

Y Tsukamoto, T Hiono, S Yamada, K Matsuno, A Faist, T Claff, J Hou, V Namasivayam, A Vom Hemdt, S Sugimoto, JY Ng, MH Christensen, YM Tesfamariam, S Wolter, S Juranek, T Zillinger, S Bauer, T Hirokawa, FI Schmidt, G Kochs, M Shimojima, Yi-S Huang, A Pichlmair, B M Kümmerer, Y Sakoda, M Schlee, L Brunotte, CE Müller, M Igarashi, H Kato. Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication; Science 379 (6632), 586-591

T Claff, JG Schlegel, JH Voss, VJ Vaaßen, RH Weiße, RKY Cheng, S Markovic-Mueller, D Bucher, N Sträter, CE Müller. Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction; Communications chemistry 6 (1), 106

T Claff. X-Ray Crystallography of G Protein-coupled Receptors. Exploring Interactions with Drug Molecules. Universitäts-und Landesbibliothek Bonn

T Claff, TA Klapschinski, UKT Subhramanyam, VJ Vaaßen, JG Schlegel, C Vielmuth, JH Voß, J Labahn, CE Müller. Inside Cover: Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates; Angewandte Chemie International Edition 61 (22), e202205120

T Claff, TA Klapschinski, UKT Subhramanyam, VJ Vaaßen, JG Schlegel, C Vielmuth, JH Voß, J Labahn, CE Müller. Eine einzige stabilisierende Punktmutation ermöglicht hochaufgelöste Co-Kristallstrukturen des Adenosin-A2A-Rezeptors mit Preladenant-Konjugaten; Angewandte Chemie 134 (22), e202115545

CE Müller, T Claff. Activated microglia nibbling glycosaminoglycans from spinal cord perineural nets: a new mechanism for neuropathic pain; Signal Transduction and Targeted Therapy 7 (1), 333

A Temirak, JG Schlegel, JH Voss, VJ Vaaßen, CVielmuth, T Claff, CE Müller. Irreversible Antagonists for the Adenosine A2B Receptor; Molecules 27 (12), 3792

S Gao, L Song, T Claff, M Woodson, K Sylvester, L Jing, RH Weiße, Y Cheng, N Sträter, L Schäkel, M Gütschow, B Ye, M Yang, T Zhang, D Kang, K Toth, J Tavis, AE Tollefson, CE Müller, P Zhan, X Liu. Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors; Journal of Medicinal Chemistry 65 (24), 16902-16917

S Gao, K Sylvester, L Song, T Claff, L Jing, M Woodson, RH Weisse, Y Cheng, L Schäkel, M Petry, M Gütschow, AC Schiedel, N Sträter, D Kang, S Xu, K Toth, J Tavis, AE Tollefson, CE Müller, XLiu, PZhan. Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity; Journal of Medicinal Chemistry 65 (19), 13343-13364

T Claff, J Yu, V Blais, N Patel, C Martin, L Wu, GW Han, BJ Holleran, O Van der Poorten, KL White, MA Hanson, P Sarret, L Gendron, V Cherezov, V Katritch, S Ballet, ZJ Liu,  E Müller, RC Stevens. Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists; Science advances 5 (11), eaax9115

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