- Pharmazeutisches Institut
- Strukturbiologie
- Cryo-Elektronenmikroskopie
- Röntgenkristallographie
- Membranproteine
- G-Protein-gekoppelte Rezeptoren
- Strukturbasiertes Wirkstoffdesign
Claff, T. et al. Structural basis for lipid-mediated activation of G protein-coupled receptor GPR55. Nature Communications 2025, 16, 1973.
Claff, T. et al. Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A2A Receptor. ACS Pharmacology & Translational Science 2024, 7(5), 1415-1425.
Claff, T. et al. Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction. Communications Chemistry 2023, 6(1), 106.
Claff, T. et al. Inside Cover: Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates. Angewandte Chemie Int. Ed. 2022, 61(22), e202115545. (Hot Paper, Inside Cover Story)
Claff, T. et al. Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists. Science Advances 2019, 5(11), eaax91
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