PhD, Master, and Diploma Theses

PhD Theses

2024

  • Dr. Tim Keuler
    Development of Molecular Chimeras Targeting the NLRP3 Inflammasome and HDAC6

2023

  • Dr. Lan Phuong Vu
    Tool Compounds to Study Proteolytical Events: Development of von Hippel-Lindau (VHL) Ligands and Combinatorial Generation of Serine Protease Inhibitors

2022

  • Dr. Carina Wirtz

    Synthesis and Bioanalytical Evaluation of Inhibitors and Tool Compounds for Human, Protozoal, and Viral Cysteine Proteases

2020

  • Dr. Christian Steinebach

    Design and Synthesis of Molecular Chimaeras for the Induced Degradation of Tumour-associated Proteins

  • Dr. Martin Mangold
    Biological Evaluation of Serine Protease Inhibitors and Inducers of Protein Degradation

  • Dr. Patrick Jim Küppers

    Design, Synthesis and Characterization of Heterocyclized Dipeptide Derivatives as Inhibitors for Heterotrimeric Gαq Proteins

2019

  • Dr. Christian Breuer

    Design and Syntheses of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins

  • Dr. Erik Gilberg

    Design Computational Analysis of Assay Interference and Compound Promiscuity in Medicinal Chemistry

2018

  • Dr. Anna-Christina Schulz-Fincke

    Kinetic and Biological Evaluation of Fluorescent Probes and Irreversible Inhibitors for Selected Human Proteases

2016

  • Dr. Anna-Madeleine Beckmann

    Identification and Characterization of Putative Interaction Partners of the Cell Surface Serine Protease Matriptase-2

  • Dr. Janina Schmitz

    Synthesis and Biological Evaluation of Nitrile-Based Peptidomimetic Inhibitors for Cysteine Cathepsins

  • Dr. Norbert Furtmann
    From Computational Analysis of X-ray Structures of Ligand-Target Complexes to Structure-based Compound Design, Synthesis, and Biochemical Evaluation

  • Dr. Daniela Häußler

    Synthesis and Evaluation of Phosphono Dipeptides as Irreversible Inhibitors and Activity-based Probes for Matriptase-2

2014

  • Dr. Matthias Mertens

    Coumarin, a Versatile Scaffold in Pharmaceutical Chemistry: Fluorescent Labeling of Amino Acids, Activity-Based Probing of Human Cathepsin S, Monoamine Oxidase B Inhibition and Chiral Derivatization

2013

  • Dr. Eva Maurer

    Characterisation of the type II transmembrane serine protease matriptase-2: Analysis of expression, activity modulation and enzyme-ligand interaction

2012

  • Dr. Philipp Aaron Ottersbach

    Investigations on Atropisomerism in Azadipeptides and Preparation of Conformationally Constrained Azadipeptides

  • Dr. Maxim Frizler
    Development of Selective Nitrile Inhibitors and 'Activity-Based' Probes for Human Cathepsins K and S

2011

  • Dr. Stefan Dosa

    Sulfamoylbenzamidine als Arginin-Mimetika: Hemmung von Trypsin-artigen Serinproteasen und Mapping des aktiven Zentrums von Matriptase-2

2010

  • Dr. Mihiret Tekeste Sisay

    Virtual compound screening and SAR analysis: method development and practical applications in the design of new serine and cysteine protease inhibitors

  • Dr. Hans-Georg Häcker
    Substituted Aromatic (Thio)ureas and Derived Heterocycles as Modulators of P-Glycoprotein and Multidrug Resistance-Associated Protein 1

2008

  • Dr. Camino M. Gonzalez

    Enzymkinetische Charakterisierung niedermolekularer Verbindungen als Inhibitoren von Serinhydrolasen

2007

  • Dr. Paul Wilhelm Elsinghorst

    Dual-mode cholinesterase inhibitors targeting muscarinic receptors

2006

  • Dr. Reik Löser

    Synthese von Dipeptid-Derivaten und deren Interaktion mit Papain-ähnlichen Cysteinproteasen unter besonderer Berücksichtigung von Dipeptidnitrilen

  • Dr. Sonja Kolp

    Untersuchungen zur Beeinflussung der Zymogen-Aktivierung durch kompatible Solute und zur proteolytischen Aktivität von Matriptase-2

  • Dr. Agnieszka Ambrozak

    Synthesis of 5-Aminobarbituric Acids and Their Conversion to Hydantoins and Bioactive Phthalimido Derivatives

  • Dr. Markus Pietsch

    Synthese tricyclischer 1,3-Oxazin-4-one und kinetische Analyse der Hemmung der Cholesterolesterase und der Acetylcholinesterase

2005

  • Dr. Manuela Meusel

    Entwicklung neuer Syntheseverfahren für biologisch aktive Ureide und Hydantoine


Master Theses

2024

  • Vesa Krasniqi
    Enzyme Kinetic Investigations on Inhibition of Cathepsins and Monoamine Oxidases

    by Low Molecular Weight Compounds

2023

  • Johannes Sievers
    N.N.
  • Elsjon Sula

    Synthesis of PET Precursors for VHL-based PROTACs

2022

  • Marie Möller

    Synthesis and Characterization of a New Non-covalent KEAP1 Ligand for PROTAC Applications

  • Sophie Wittenburg

    Synthesis and Physicochemical Characterization of PROTACs Targeting RAF Kinases

2020

  • Sabine Anna Voell

    Synthesis of PROTACs Targeting BRAF(V600E)

2019

  • Dominik Brajtenbach

    Synthesis of Cyanine-Containing Activity-Based Probes for Cathepsin-K

  • Jiafei Yin

    Biochemical Investigation of Inhibitors and Tool Compounds for Different Human Proteases, Esterases and Oxidases

2018

  • Lan Phuong Vu

    Synthesis of E3 Ligase Ligands as Building Blocks for PROTACs

  • Seyda Teke

    Synthesis of Dipeptidomimetic Carbamates as Cathepsin B Inhibitors and Precursors for Positron Emission Tomography

2017

  • Franziska Kohl

    Synthesis and Biological Evaluation of a Novel BIP-V5 Containing PROTAC Targeting the Human Bax Protein

  • Carina Lemke

    Development and Enzymatic Characterization of Covalent Inhibitors Adressing Various Human Cathepsins

2016

  • Christian Steinebach

    Design of Phthalimide-Conjugates for Bifunctional Ligand-Based Target Protein Degradation

  • Polya Georgieva Roydeva

    Untersuchung zur Hemmung von Matriptase-2 durch ausgewählte heterocyclische Verbindungen

  • Lisa Reinelt

    Synthese analoger BIM-46187-Derivate

  • Tianwei Li

    Kinetic Evaluation and Structural Optimization of Dipeptidyl Nitrile Type Cathepsin B Inhibitors

2015

  • Laura Cremer

    Synthesis of Dipeptide Carbamates and Dipeptide Carbonates as Inhibitors of Cysteine proteases

  • Tamara Scheidt

    Kinetic Investigations on Pharmaceutically Relevant Serine and Cysteine Proteases with Selected Protease Inhibitors 

  • Martin Mangold

    Untersuchungen zur Reinigung und Aktivitätsregulation der rekombinanten humanen Serinprotease Matriptase-2

2013

  • Karina Scheiner

    Affibody-based Enzyme Scaffolds for Metabolic Engineering of E. coli and Cyanobacteria for Improved PHB and Butanol Production in Vivo (Universität Bonn / Royal Institute of Technology, Stockholm)

  • Anna Beckmann

    Synthesis of 3-Cyano-3-aza-ß-amino Acid Derivatives as Potential Inhibitors of Human Cysteine Proteases

  • Verena Lülsdorff

    Charakterisierung von Hepatocyte Growth Factor Activator Type 1 (HAI-1) als Inhibitor der Serinprotease Matriptase-2

  • Michael Lülsdorff

    Synthesis of Dipeptidomimetics with Inversely Oriented Warheads and their Inhibitory Activity Against Cathepsin B

  • Katharina Arenz

    Evaluation of Nitroxoline-Related Compounds in a 3D In Vitro Tumour Invasion Model (Universität Bonn / University of Ljubljana)

2012

  • Franziska Krumbiegel

    Methodenvalidierung eines Alkoholmarkers in Mekonium (Universität Bonn / Institut für Rechtsmedizin der Charité Berlin)

2011

  • Daniela Häußler

    Synthese Fluoreszenz-markierter Serinprotease-Inhibitoren 

  • Janina Schmitz

    Synthesis and Evaluation of P2-Modified Dipeptide Nitriles as Inhibitors of Cathepsin S

2009

  • Matthias Mertens

    Synthesis of N- and O-sulfonylated 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine / Quinazoline Derivatives and Observation of a N-O Sulfonyl Transfer

  • Eva Maurer

    Charakterisierung des Aktivierungsmechanismus der Trypsin-ähnlichen Serinprotease Matriptase-2


Diploma Theses

2012

  • Lukáš Hroch

    Preparation of 3,5,5-Trisubstituted Hydantoins From Activated Cbz-Aminomalonic Acids (Universität Bonn / Univerzita Karlova v Praze)

2009

  • Friederike Lohr

    Aza-Dipeptidnitrile als potentielle Cysteinprotease-Hemmstoffe: Synthese und enzymkinetische Untersuchungen

  • Philipp Aaron Ottersbach

    Synthese von potentiell biologisch aktiven Benzo[1,2-d:4,3-d']bisthiazolen und 3,1-Benzothiazinen

2008

  • Cornelius Heß

    17-Hydroxymethyl-17-methyl-18-nor-Derivate als Metaboliten von anabolen androgenen 17alpha-Methyl-Steroiden - massenspektrometrische Charakterisierung und renale Elimination (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln)

  • Maxim Frizler

    Azadipeptidnitrile als Proteaseinhibitoren: Synthese, Stabilität und Papain-Hemmung

2007

  • Mihiret Tekeste Sisay

    Homology Modeling and Structural Analysis of the Catalytic Domain of Matriptase-2

  • Anne-Katrin Orlovius

    Metabolismus von Stimulanzien: Synthese und direkte Bestimmung von Sulfat-Konjugaten. Ein Beitrag zur Weiterentwicklung des Nachweisverfahrens in der Dopinganalytik (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln)

2006

  • Eva Lepicova

    Investigations on the Darzens Condensation of 2-Bromo-4,6-dimethoxybenzofuran-3(2H)-one (Universität Bonn / Univerzita Karlova v Praze)

  • Jürgen Gäb

    Synthese von 4H-3,1-Benzothiazin-4-on-Derivaten als potentielle Liganden von Adenosin-Rezeptoren

2004

  • David Bolek

    Syntéza derivátu alfitoninu (Universität Bonn / Univerzita Karlova v Praze)

2002

  • Ales Marecek

    Syntéza 2-benzyl-2-hydroxy-2H-benzofuran-3-onu (Universität Bonn / Univerzita Karlova v Praze)

  • Abdelazim Sarhan

    Untersuchungen zur Synthese und zur D-Hydantoinase-katalysierten Hydrolyse von Hydantoinen

2001

  • Markus Pietsch

    Untersuchungen zur Wechselwirkung von Pankreas-Cholesterolesterase mit niedermolekularen Verbindungen

2000

  • Lars Kuerschner 

    Untersuchungen zur Enzymkinetik und zur Enzym-Ligand-Wechselwirkung von Cathepsin G-Inhibitoren

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